THE INFLUENCE OF DIFFERENT BINDERS COMBINED WITH DISINTEGRANT IN THE TROCHES OF HABBATUS SAUDA ‘ (Nigella sativa L.) EXTRACT

Sucita, Anugerah (2018) THE INFLUENCE OF DIFFERENT BINDERS COMBINED WITH DISINTEGRANT IN THE TROCHES OF HABBATUS SAUDA ‘ (Nigella sativa L.) EXTRACT. Diploma thesis, University of Darussalam Gontor.

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Abstract

Habbatus sauda' (Nigella sativa L.) has been examined has the content of flavonoid compounds that act as antioxidants. In order to be utilized more effectively and efficiently, it needs to be made innovation preparations with active substances habbatus sauda'. One of the innovations of preparations that can apply habbatus sauda' as the active substance is troches. This research was conducted to find out the influence incurred due to the difference in binder combined with disintegrant on the troches dosage habbatus sauda' extract. Binders used are amylum manihot and PVP while disintegrant used is Avicel PH 102. The troches’ made in four different formulas. Formula 1 using 5% concentration of amylum manihot and 15% concentration of Avicel PH 102, formula 2 using 10% concentration of amylum manihot and 20% concentration of Avicel PH 102, formula 3 using 5% concentration of PVP and 15 % concentration of Avicel PH 102, while formula 4 using 10% concentration of PVP and 20% concentration of Avicel PH 102. The method used in the manufacture of troches is wet granulation with 70% ethanol spraying. On the stage of preformulation, carried out an analysis of halal ingredients. The analysis shows that the critical point of halal ingredients used in the formulation is not found. The results of the evaluation of physical characteristics of granule and tablet indicate that the difference in binders combined with disintegrant affect the physical characteristics of granule and tablet. The best formula is the Formula 3 with an average value of hardness 8,69 kg/cm3 and the friability 0,54%. Key Words: Binder, Disintegrant, Troches, Habbatus sauda

Item Type: Thesis (Diploma)
Subjects: Q Science > Q Science (General)
Divisions: Fakultas Ilmu Kesehatan UNIDA Gontor > Farmasi
Depositing User: Mr Muhammad Taufiq Riza
Date Deposited: 05 Nov 2020 04:04
Last Modified: 05 Nov 2020 04:04
URI: http://repo.unida.gontor.ac.id/id/eprint/709

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