The development of religion-based science was not only a scientific problem, but also a social and Islamic problem. The problem is not merely related to efforts of finding a basis of philosophy of science and methodology support, but also an attempt to reconstruct pub- lic mind set and understanding of Islam. This article will look at some of the key concepts of Islam, which provide a fertile ground for the development of science, although some might view these concepts as barriers for the growth and development of science. The fundamental solution to this problem is urgent to be given to find a wider space for a negotiation between religion (Islam) and science. In the end of the day, a higher effort to develop Islamic science with its religious and scientific ground can be exerted and achieved.