Cigarette smoke is a source of exogenous free radicals that can stimulate the secretion of inflammatory mediators. Flavonoid is a compound contained in marigold leaves, believed to have anti-inflammatory effects. This study aims to look at the effect of giving marigold leaves to the profile of Wistar rat leukocytes exposed cigarette smoked. This research was an experimental laboratory research design with pre and post- control groups. The sample consisted of 30 male wistar. The control group was given food and drink in an ad libitum without giving marigold, while treatments 1 and 2 were given marigold at a dose of 4.5 and 6.3 grams. Each group was exposed to 2 cigarettes per day for 2 weeks. On days 0,7, and 14 blood samples were taken through retro orbitals. The data can be seen using the Sysmax KX-21® Hematology Analyzer. Normality test using Shapiro- wilk continued to one way ANOVA test and finally DUNCAN test. One way ANOVA test results for leukocytes, neutrophils and lymphocytes stated p = 0.00, which means that the effect of giving marigold to levels of leukocytes, neutrophils and lymphocytes of Wistar rats exposed cigarette smoked, the DUNCAN test results stated the dosage of 4.5 and 6.3 not significantly different, but gave a significant difference to the control group. And marigold significant to reduce levels of leukocytes, neutrophils, and lymphocytes to the normal stage of wistar rats exposed cigarette smoked Key Words: Cigarette smoke, Leukocyte profile, Marigold leaves