The discourse of religion and science is constantly echoed and continues to be studied mainly by several academics, including several universities. There is nothing but to strengthen the meeting point between religion and science, moreover there are some assumptions which state that religion and science cannot be united. The concept of integration is one of the efforts in the discourse of the dichotomy of religion and science, one of which is the view of Holmes Rolston, one of the philosophers who brings together theology, namely religion and theory, namely science in methodology. Through Holmes Rolston's methodological concept, the integration between religion and science can grow and develop and even complement each other. In this study, the author uses a qualitative approach with the library study method. From the study that the author conducted on Holmes Rolston's view on the integration of religion and science, as a response to the sychotomy of religion and science, the answer is that between theology, namely religion and theory, namely science, can meet in a methodology.