Zakiah Daradjat is a Religious Psychologist who reformulated the concept of ‘Mental Hygiene’ to treat Indonesian adolescent problems. Accordingly, religious values that were not included in the previous version of the concept are the most crucial point. Main idea of this concept is Avicenna’s concept of the relation between body and the soul, which becomes the principle of mental hygiene. This research utilizes religious psychology approach and a grounded research method to elaborate issues related to nowaday Indonesian adolescents; confirming the relevance of Daradjat's mental hygiene concept challenging such problems. This research indicated: First, the concept of mental hygiene is still significant to be applied in Daradjat’s educational institution: Ruhama; second, the provisional results displayed positive response of the adolescents who were the samples in this study; while the preliminary results of the analysis of the mapping of adolescent problems, may be answered with the concept of Daradjat’s mental hygiene.