The Covid-19 phenomenon has resulted in the hospital employees to have extra work, as the first forefront to overcome the impact of Covid-19. As the result, the hospital's performance has decreased significantly. This study aims to explain the influence of competence and Islamic teamwork towards the performance with work stress as intervening variable. This research used a quantitative descriptive method with total sample of 98 respondents from some Islamic Hospitals employees through questionnaires by using Partial Least Square (PLS) as the analysis method. The results showed that competence influences performance at P values of 0.011 < 0.05, Islamic teamwork influences performance at P values of 0.000 < 0.05, competence does not influence work stress at P values of 0.655 > 0.05, Islamic teamwork does not influence work stress at P values of 0.869 < 0.05, work stress influences performance at P values of 0.046 < 0.05, competence does not influence performance mediated work stress at P values of 0.615 > 0.05, and Islamic teamwork does not influence performance by mediated work stress at P values of 0.854 > 0.05. Those, the result could be concluded as increasing the competence and Islamic teamwork of Islamic Hospitals employees will reduce to face out work stress in producing good performance optimally.