The mouth is one of the organs that often becomes a focal (spreading process) of infection in some cases in infection of vital organs. In the mouth, saliva is produced which has a major role in cleaning the mouth by keeping the mucosal membrane moist, regulating the Potential of Hydrogen (pH) of saliva and digesting food. pH of salivary is a liquid consisting of a mixture of secretions from the salivary glands contained in the oral cavity with an acidity of 6-7. This study aims to determine the effect of rinsing the mouth with lemon and honey solution on the pH and volume of saliva. This study was a experiment using respondents who had thrush and dental caries as many as 40 people. The treatment was in the form of gargling activities which were divided into 5 treatment groups, namely positive control (povidone iodine), negative control (mineral water), honey solution 1%, 2%, 3% and lemon solution 1%, 2%, 3%. Samples in the form of saliva taken before and after treatment by the spitting method. pH of saliva measurement uses Ohaus pH meter and for saliva volume measurement using saliva tubes with a volume scale. Data in the form of pH and saliva volume were analyzed using the Paired T-test, Wilcoxon, and Kruskal Wallis with an SPSS version 16 and a significance level of 95%. The results in this study show that rinsing the mouth using a solution of trigona honey can lower the pH of saliva when the concentration is higher. While rinsing the mouth using lemon solution can increase the pH of saliva. Although statistically the increase and decrease in pH is not significant (p>0.05). In the saliva volume test using honey solution can increase the volume of saliva. While rinsing the mouth using lemon solution can lower the volume of saliva. Although statistically the increase and decrease in volume is not significant (p>0.05). The conclusion in this study is that rinsing the mouth using a solution of trigona honey can reduce the pH of saliva if the concentration in the solution is increased, while rinsing the mouth using a lemon solution can increase the pH of saliva. And rinsing the mouth using a solution of trigona honey can increase the volume of saliva, while rinsing the mouth using a lemon solution can lower the volume of saliva, at a decrease in the level of pain a solution of trigona honey can lower the level of pain more effectively compared to a lemon solution.