Knowledge regarding the selection of halal and safe cosmetic products is currently really needed. During 2021, 202,304 types of cosmetics have distribution permits by the Indonesian POM. The number of discoveries of illegal products is a separate warning for consumers to be smart in choosing products with safe ingredients by those specified in the BPOM statement and choosing materials that are allowed in Islam. The POM Agency states that several criteria for cosmetics that can be categorized as safe must include the use and how to use them, not containing harmful chemicals, labels, packaging, marketing permits, and expiration dates. Then the halal aspect of cosmetics refers to the ingredients in them. Good material is not only seen from its safety but also must be clean and holy. The type of research used is observational research with cross-sectional method. The results were that there were 62 respondents (65%) in the pretest and 76 respondents (80%) in the posttest have good knowledge regarding halal and safe cosmetics. Meanwhile, there were 33 respondents (35%) in the pretest 19 respondents (20%) in the sufficient category. The results obtained in the simple linear regression test are 0.445, which is <0.05. This indicates that there was no significant effect between the level of knowledge of the respondents and the selection of halal and safe cosmetics.