Khoiriyah, Nisaul (2025) FORMULATION OF SPRAY PREPARATIONS OF BIDARA LAUT LEAVES EXTRACT (Ziziphus mauritiana L.) AND EFFECTIVENESS IN HEALING BURNS OF WISTAR STRAIN WHITE RATS. S1 Undergraduate thesis, Universitas Darussalam Gontor.

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Abstract

Burns are skin and body tissue injuries caused by various factors, including heat, chemicals, electricity, and radiation. The damage inflicted can range from mild to severe, potentially life-threatening. Wounds that are not treated properly will cause the death of some cells or all skin cells or organic tissue. Burns have several degrees of severity, classified into degrees I, II, and III. The wound healing process occurs in 4 phases, namely the inflammation phase, proliferation phase, maturation phase and remodelling phase. To accelerate the healing process of burn wounds, you can use bidara leaf extract because it contains flavonoids, alkaloids and tannins. This research aims to prepare a bidara laut leaf (Ziziphus mauritiana L) extract spray, which can be evaluated by testing its effectiveness on burn wounds in white rats. This experimental research involves making three spray formulations with concentrations of bidara leaf extract: F0, F1, F2, and F3, with excipients of propylene glycol and 96% ethanol. Evaluation of the physical quality of the preparation includes visual tests, homogeneity tests, pH tests, adhesion tests and irritation tests. Meanwhile, the effectiveness test on burns on white rats was conducted 2 x 1 day in the morning and evening with three pumps and conducted until the wound had healed. Data analysis used the Kruskal Wallis test with SPSS 16.0 and a significance level of 95%. The research showed that the spray preparation of bidara leaf extract had good results, was homogeneous, met pH and adhesion standards, and did not cause irritation to the skin. A spray preparation of sea bidara leaf extract effectively accelerated the healing process of burn wounds in white Wistar rats (p<0.05). The spray preparation of bidara leaf extract formula I with an extract concentration of 2.4 grams had the fastest effect on healing burns in Wistar white rats, with an average healing time of 7 days.

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