Nabilah, Yumna Amirotin (2025) The Effect of Suweg Tuber Flour (Amorphophallus paeoniifolius) and Bambara Groundnut Flour (Vigna subterranean) Formulation on Blood Glucose Levels and Atherogenic Index (Study on Sprague Dawley Diabetic Dyslipidemia Rats). S1 Undergraduate thesis, Universitas Darussalam Gontor.

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Abstract

One of the complications of Type 2 Diabetes Mellitus (T2DM) that increased prevalence was Atherosclerosis Cardiovascular Disease (ASCVD). A new parameter to measure ASCVD is the Atherogenic Index of Plasma (AIP). Consumption of foods high in fiber and antioxidants can lower blood glucose levels and lipid profiles. One of the food sources of fiber and antioxidants is the suweg tuber and bambara groundnut. This study aimed to analyze the effect of a formulation of suweg tuber flour and bambara groundnut flour on blood glucose levels and the atherogenic index in diabetic dyslipidemia rats. The research method was a pre-and post-test with a randomized control group design. This study used 30 male Sprague Dawley rats aged 8-10 weeks with a weight range of 150-200 grams. The rats were divided into five groups: K(-) diabetic dyslipidemia rats without treatment, K(+) diabetic dyslipidemia rats treated with atorvastatin, and groups P1, P2, and P3, which were diabetic dyslipidemia rats treated with a formulation of suweg tuber flour and bambara groundnut flour at 2.5 grams/200 g body weight/day, with the ratios of P1 (75%:25%), P2 (50%:50%), and P3 (25%:75%) for 14 days. Blood glucose levels were measured using the GOD-PAP method, and the atherogenic index was calculated using the formula log(triglycerides/HDL). Data analysis was performed using One-Way ANOVA with post-hoc Tukey and Paired T-test. The results showed that group P1 experienced the highest reduction in blood glucose levels, 136.5 ± 6.6 mg/dl (p=0.000), and a decrease in the atherogenic index of 0.37 ± 0.03 (p=0.000). Meanwhile, group K(-) showed an increase in blood glucose levels of 1.7 ± 0.8 mg/dl and an increase in the atherogenic index of 0.02 ± 0.01. In conclusion, the formulation of suweg tuber flour and bambara groundnut flour in the P1 ratio significantly reduced blood glucose levels and the atherogenic index.

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