Jagaddhita Widyadhana, Farras (2025) THE EFFECT OF SUWEG TUBER FLOUR (Amorphophallus campanulatus) AND BAMBARA GROUNDNUT FLOUR (Vigna subterranea) FORMULATION ON TOTAL CHOLESTEROL AND TRIGLYCERIDE LEVELS (Study on Male Sprague-Dawley Rats Diabetic dyslipidemia). S1 Undergraduate thesis, Universitas Darussalam Gontor.

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Abstract

Diabetic dyslipidemia was an imbalance in lipid (fat) levels in the blood, such as cholesterol and triglycerides. This study to analyze the effect of intervention with suweg tuber flour and bambara groundnut flour formulations on total cholesterol and triglyceride levels in diabetic dyslipidemia Sprague-Dawley rats. The research method is true experimental design with a pre-post test and a randomized control group design. The research was conducted at the Center for Food and Nutrition Studies Laboratory, Universitas Gadjah Mada. The study used 30 male Sprague-Dawley rats, aged 2 to 3 months, with a body weight of 150 to 200 grams, grouped into 5 groups based on the Federer formula. The treatment was carried out for 14 days. Total cholesterol levels were examined using the CHOD-PAP method, and triglyceride levels using the GPO-PAP. The groups were as follows: (K1) STZ-NA+HFD+ standard diet, (K2) STZ-NA+HFD+atorvastatin 0.36 mg/200 gBW/day, (P1) STZ-NA+HFD+ 1,9 g suweg tuber flour + 0,6 g bambara groundnut flour, (P2) STZ-NA+HFD+ 1,25 g suweg tuber flour +1,25 g bambara groundnut flour, and (P3) STZ-NA+HFD+ 0,6 g suweg tuber flour +1,9 g bambara groundnut flour. Statistical analysis used a Paired T-test test and One-Way ANOVA test followed by Post Hoc Tukey (p-value <0,05). The results showed a significant difference in total cholesterol and triglycerides between groups before and after treatment; there was a significant difference in the mean of total cholesterol and triglycerides between groups before and after treatment and there was a difference in total cholesterol in each group (p=0.000). Formulation P2 was most effective in reducing total cholesterol levels (44.54 mg/dL), while formulation P1 was most effective in reducing triglyceride levels (28.94 mg/dL). The formulations of suweg tuber flour and bambara groundnut flour were able to reduce total cholesterol and triglyceride levels in male Sprague-Dawley rats with diabetic dyslipidemia model.

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