The widespread implementation of technology encourages the increase in the use of machines in various industrial processes. The intensive use of machines is expected to optimize productivity and production efficiency consistently. Continuous exposure to machine noise can trigger stress and psychological disorders in workers, which ultimately leads to decreased productivity and causes work fatigue. Darussalam Gontor modern islamic boarding school Ponorogo operates a number of business units to meet the large production demand, so that the production process of machines at a high speed to achieve the daily target of production, this speed increases vibration which can produce a high level of noise. This study aims to analyze the relationship between noise intensity and work fatigue in printing and convection workers of the Darussalam Gontor Ponorogo business unit. This study uses a cross-sectional quantitative approach to study the correlation between noise and work fatigue in 67 workers in Darussalam Press and La-Tansa Convection of the Darussalam Gontor business unit, which were selected through purposive sampling techniques from a total population of 131 workers. The study, which was conducted in November 2024- January 2025, found a significant relationship between noise and work fatigue (p<0.05) with noise levels in the printing area exceeding the NAV of 85 dBA, while other areas were below the NAV. The majority of respondents (86%) experienced mild work fatigue, followed by 11% moderate fatigue, and 3% severe fatigue. Therefore, it is recommended to implement a hierarchy of control in the form of providing dampers to machines, providing Personal Protective Equipment (PPE) to reduce work fatigue levels and increase productivity and worker welfare. Keywords: Noise Intensity, Work Fatigue and Darussalam Gontor Business Unit