Rahmania, Rizka Azkia (2025) THE EFFECT OF SUWEG TUBER FLOUR (Amorphophallus paeoniifolius) AND BAMBARA GROUNDNUT FLOUR (Vigna subterranea) FORMULATION ON HDL AND LDL LEVELS (Study on Sprague Dawley Diabetic Dyslipidemia Rats). S1 Undergraduate thesis, Universitas Darussalam Gontor.

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Abstract

Diabetic dyslipidemia was common metabolic disorder in individuals with diabetes mellitus, characterized by decreased HDL levels and increased LDL levels. One of the preventive measures that can be taken is increasing fiber intake, which plays a role in improving the lipid profile. Suweg tuber flour (Amorphophallus paeoniifolius) and bambara groundnut flour (Vigna subterranea) were local food sources rich in fiber and can improve blood lipid levels. This study aims to analyze the effect of a formulation of suweg tuber flour and bambara groundnut flour on HDL and LDL levels in diabetic dyslipidemia rats. The research a true experimental design with a randomized pre-test and post-test controlled group design. The study subjects consisted of 30 male Sprague-Dawley rats, randomly divided into five groups: a negative control group (K-), a positive control group (K+) given atorvastatin (0.36 mg/200 g body weight/day), and three treatment groups (F1, F2, and F3) given formulations of suweg tuber flour and bambara groundnut flour with ratios (75%:25%, 50%:50%, and 25%:75%), respectively. Data analysis was conducted using the Shapiro-Wilk normality test, paired t-test, homogeneity test, and one-way ANOVA, followed by the Post Hoc Tukey test. The results showed a significant effect after the intervention (p<0.05). The F1 group exhibited the highest mean HDL level (77.2 ± 2.0 mg/dL) and the lowest mean LDL level (27.0 ± 1.5 mg/dL) compared to the other groups. Statistical analysis indicated significant differences between groups with p-values for HDL and LDL equal to 0.000. This study concludes that suweg tuber flour and bambara groundnut flour effectively increase HDL levels and reduce LDL levels in diabetic dyslipidemia rats, with the most effective formulation being F1.

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