Modules are one form of teaching material that can help students learn independently. For students to receive materials well, it is necessary to create a learning atmosphere by the characteristics of students. Differentiated instruction approach is a learning approach by giving different instructions according to the features of the learner. This research aims to test the effectiveness of learning methods with a differentiated instruction approach compared to differentiated instruction-based modules. This research is a pseudo-experimental study with 92 students of the Informatics Engineering study program of Darussalam Gontor University. Modules are one form of teaching material that can help students learn independently. For students to receive materials well, it is necessary to create a learning atmosphere by the characteristics of students. This research began by giving treatment in learning as many as six meetings on Derivative materials The data analysis in this study uses Oneway ANOVA. Before data analysis, the prerequisite of research is a test of normality and homogeneity. The results of the analysis prerequisites are obtained that the data is distributed normally and homogeneously. The results concluded that there were significant differences between students who were tau