Anemia occurs when the number of red blood cells decreases, so that the ability to carry oxygen throughout the body will decrease. Globally, the prevalence of anemia is 1.62 billion, where the majority of anemia sufferers are women who are not pregnant as many as 468.4 millions of people. The highest prevalence of anemia is that of girls at school age, 47.4%, while for men it is only 12.7%. The need for iron intake in a woman has a greater need compared to the needs of men. Objective: to determine the relationship between micronutrient intake (vitamin B6, vitamin B12, vitamin C, iron) and the incidence of anemia in adolescent girls in Islamic boarding schools. Methods: Case control with matching, matching criteria used aged 15-19 years, not menstruating at the time of checking Hemoglobin, not fasting, and already experiencing menstruation, data collection using non-probability, namely by quota sampling, the population was 1359 with a sample of 92 people , case 46 people control 46 people, data retrieval with Semi Quantitative Food Frequency (SQ-FFQ) questionnaire. Tests using paired 2 statistical tests. Results: there was a significant relationship between micronutrient intakes (vitamin C p-value 0.04, OR 1.17, vitamin B6 p-value 0.0001 OR 3.588, vitamin B12 (p-value 0.0001) OR 0.27, iron (p-value 0, 0001) OR 3,091) with the incidence of adolescent anemia in Islamic boarding schools. . Conclusion: There is a significant relationship between micronutrient intake and the incidence of anemia in adolescents in Islamic boarding schools.