Human presence is closely related to the role of God as a creator. People have the natural nature of not denying the existence of God, and people desperately need the existence of God to have a handle in life so that what they do becomes more meaningful and gives hope for a happy ending. Furthermore, the destiny of man in the Qur'an is that Allah has given a particular degree or measure or limit in the person, nature, or maximum ability of His being. The position of destiny in human life is not determined in eternal times but along with the ongoing process. This article was written using the method of documentation study in the analysis of the concept between God and man on Toshihiko Izutsu perspective. As a result, Izutsu described the four relationships between God and Man. Firstly, The Ontological Relationship which discussed a relation between God and man, that God as creator and man as a human being. Following the first, there are a Communicative Relationship between God and man which brought into close correlation through mutual communication. So comes the third, was Master-servant relationship, that God as Master (Rabb), and man as a servant (abd). And the final was Ethical Relationship, which discussed an Ethic doing on a man obligation on his God, nor God's commandments or prohibitions and how God will on His creatures.