The relationship between science and religion is that there is a relationship between the two in history has clashed. For Islamic science, religion is inherently inseparable from science. Islamic science adheres to dîn or religion. Islam is based on the revelation of the Holy Qur'an. Syed Muhammad Naquib al-Attas and Ian G Barbour are very influential figures in the world of Education, especially in the field of Religion and Science. Al-Attas is famous for his ideas of Religious Integration and Science. For Muslim scientists the Qur'an is a source of knowledge from which all disciplines are developed. Shari'ah such as, Aqidah and Fiqh, using comparative descriptive this paper finds in the integration of religion and science The Upper Al-through the classification stage of three elements: the infinity of science, the glory of responsibility for seeking it and the limitations of human life. Ian G. Barbour has an opinion on the integration between religion and science of relationships that is intensively observed from the relationship approach by seeking the right integrity of science and religion