Mahmud, Mardina (2024) RATIONALITY OF NONSTEROIDAL ANTI-INFLAMMATORY DRUGS (NSAID) TREATMENT IN HOSPITALIZED PATIENTS WITH IMPAIRED KIDNEY FUNCTION AT Dr. MOEWARDI HOSPITAL. S1 Undergraduate thesis, Universitas Darussalam Gontor.

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Abstract

Kidney failure is a disease with decreased kidney function in eliminating metabolic waste and regulating electrolytes acids, and bases. Patients with a 60% decreased kidney function experience pain. The first-line treatment for pain is NSAIDs. Patients with decreased kidney function have pharmacokinetic parameters the differ significantly from patients with normal kidney function. The appropriate selection of medication and dosage is essential for patients with reduced kidney function to avoid adverse drug reactions and ensure optimal treatment effectiveness. The purpose of this research was to evaluate the description and the rationality of NSAID prescriptions in hospitalized patients with decreased kidney function in hospitals. This research is a non-experimental with a retrospective method. It employs descriptive data analysis by reviewing patient medical record data for the period January-December 2023. The result of this study found 160 inpatients with impaired kidney function receiving NSAIDs. The results obtained from the description of the most widely used prescriptions were non-selective NSAIDs, namely metamizole injection 1000mg/ml in 80 patients (50%) and antrain (metamizole) 500mg/ml in 43 patients (26,8%). The type of non-selective NSAID drugs used at Dr. Moewardi Hospital include metamizole, antrain, ketorolac, diclofenac sodium, and ibuprofen, this is because selective NSAIDs are more likely to increase blood pressure and increase sodium retention, so they can worsen kidney function. In measuring the rationality of NSAID treatment in patients with decreased kidney function, namely 100% correct indication, 9,4% correct drug, 8,2% correct dose, 8,2% correct rule of use, and the potential increase in serum creatinine 5%.

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