Hypertension is a condition characterized by an increase in systolic blood pressure of ≥140 mmHg and diastolic blood pressure of ≥90 mmHg. This condition is often referred to as a "silent killer" because it can lead to serious complications, such as stroke and heart disease, if not properly managed. This study aims to examine the effects of antihypertensive therapy and Qur’an recitation on blood pressure and the quality of life of hypertensive patients. The method used is a quasi-experimental design with a pre-test and post-test approach. The study involved three groups: antihypertensive therapy without Qur’an recitation, antihypertensive therapy with Qur’an recitation once a day, and antihypertensive therapy with Qur’an recitation twice a day for three days. Data analysis used a Generalized Linear Model (GLM) to determine the effect of intervention between treatment groups on blood pressure and quality of life. Meanwhile, to determine the difference in blood pressure and quality of life before and after treatment, the data were analyzed using SPSS 16.0 with a significance level of 95%. The results showed that antihypertensive therapy combined with Quran recitation had an effect on lowering blood pressure, although it was not statistically significant, with a p-value of 0.226 for systolic blood pressure and 0.507 for diastolic blood pressure (p > 0.05). However, antihypertensive therapy combined with Quran recitation significantly improved the quality of life of hypertensive patients, with a p-value of 0.025 (p < 0.05).