Acne is a skin disorder that often appears on the face, neck, chest and back. Treatment of acne is generally done with the use of antibiotics to reduce inflammation and kill bacteria, but the use of antibiotics too often can cause bacterial resistance, so another alternative is needed by using herbal ingredients such as areca nut which contains flavonoids, alkaloids, tannins, and saponins as antibacterial compounds made in the form of a peel-off gel mask preparation. This study aims to make and evaluate the quality of areca nut extract peel-off gel mask preparation and inhibition test against the growth of Staphylococcus epidermidis bacteria. This research is an experimental study by making peel-off gel masks with variations in the concentration of areca nut extract F0 (0%), F1 (2.5%), F2 (5%), F3 (7.5%). Staphylococcus epidermidis antibacterial test using disc diffusion method. Data from the quality evaluation of the preparation were analyzed by comparing SNI standards while the results of the antibacterial activity test were analyzed using One Way ANOVA with a significance level of 95%. The results of this study indicate that the organoleptic test results are red in color, homogeneous preparation, pH 6.84-7.47 (meets SNI 16-4380-1996 standards), viscosity 2772.5-3098.9 cPs (meets SNI 16-4380-1996 standards), spreadability 4.36-5.32 cm (meets SNI 16-4380-1996 standards), drying time 21 minutes 61 seconds-27 minutes 9 seconds (meets SNI 16-4380-1996 standards). The peel-off gel mask preparation has the antibacterial ability of Staphylococcus epidermidis with the greatest inhibition, namely 7.5% extract concentration (F 3) with an average inhibition zone of 13.83 mm (p < 0.05). Keywords: antibacterial, areca nut, gel, peel-off, Staphylococcus epidermidis